Characteristics of the study population
| Joint replacement (n = 18) | No joint replacement (n = 95) | p Value | |
|---|---|---|---|
| Values are mean (SD). | |||
| p Values are for the comparison between subjects who underwent knee replacement and those who did not. Comparisons were made using Student’s t test or the χ2 test, as appropriate. | |||
| BMI, body mass index; WOMAC, Western Ontario and McMaster Universities osteoarthritis index. | |||
| Age (years) | 64.1 (9.3) | 63.1 (10.3) | 0.83 |
| Sex (per cent female) | 67% | 56% | 0.44 |
| BMI (kg/m2) | 29.9 (5.8) | 28.6 (4.9) | 0.28 |
| Tibial bone area (mm2) | 3624 (517) | 3413 (591) | 0.16 |
| WOMAC (pain, stiffness, function) | 517.4 (172.9) | 397.2 (222.5) | 0.02 |
| Pain | 102.8 (35.3) | 77.1 (41.2) | 0.02 |
| Stiffness | 51.5 (16.7) | 37.4 (22.5) | 0.01 |
| Function | 374.4 (138) | 290.0 (170.1) | 0.05 |
| Kellgren–Lawrence radiographic grade | |||
| I | 0 | 9 | 0.21 |
| II | 7 | 44 | |
| III | 11 | 42 | |
| Baseline tibial cartilage volume (mm3) | 3526 (685) | 3705 (932) | 0.34 |
| Annual loss of tibial cartilage (mm3) | 274 (208) | 194 (191) | 0.10 |
| Per cent tibial cartilage loss | 7.6 (5.8) | 5.0 (5.0) | 0.05 |