Characteristics of two patients with Felty’s syndrome and autoantibodies to GM-CSF and IL3 compared with 30 FS patients without anti-GM-CSF or anti-IL3 antibodies
| Anti-GM-CSF negative FS patients (n = 30) | Patient 26: anti-GM-CSF+, anti-IL3 + | Patient 3: anti-GM-CSF+, anti-IL3+ | |
|---|---|---|---|
| Serum from patient 26 contained neutralising antibodies to IL3 and non-neutralising antibodies against GM-CSF. Serum from patient 3 contained non-neutralising antibodies against IL3 and GM-CSF. Values for parametrically distributed values (ANC, ALC, haemoglobin, platelets) of the anti-GM/CSF/IL3 antibody negative patients with FS are displayed as means (SEM). Non-parametrically distributed values are displayed as medians (IQR). | |||
| FS, Felty’s syndrome; RF, rheumatoid factor; ANC, absolute neutrophil count; ALC, absolute lymphocyte count. | |||
| Age (years) | 62.7 (2.0) | 50 | 62 |
| Sex (F/M) | 15:15 | 1/0 | 0/1 |
| ANC (n/nL) | 2.17 (0.41) | 0.29 | 1.48 |
| ALC (n/nL) | 1.00 (0.10) | 0.94 (0.07) | 1.36 |
| Platelets (n/nL) | 12.2 (0.3) | 110.0 | 88 |
| Haemoglobin (g/dL) | 11.51 (0.65) | 9.9 | 11.2 |
| GM-CSF (pg/mL) | 2.82 (2.65–3.17) | 2.64 | 4.37 |
| IL3 (pg/mL) | 9.85 (8.94–11.91) | 15.3 | 11.63 |
| Bone marrow | |||
| Active | 13/23 | + | |
| Lymphocytosis | 3/23 | – | – |
| Left shift | 6/23 | – | – |
| RF positive | 26/29 | + | + |
| Splenomegaly | 26/30 | + | + |