Table 1

 Demographic data, drug treatment, medical history, anti-dsDNA antibodies, SLAM scores, C3/C4 levels, and CR1 levels of all six patients with SLE

PatientSex/age/onset of diseaseCurrent drug for treatment of SLEClinical manifestation*Anti-dsDNA† (Farr titre, U/ml) ANA titre ENA profileSLAM Day 0/day 28C3/C4 (g/l) t = 0 h t = 4 h t = 24 h t = 48 hCR1 on RBC
*Clinical manifestation may be acute or in the medical history; †baseline levels of anti-dsDNA antibodies before entering the study; ‡levels at screening visit (2 weeks before) were 0.82/0.19.
ENA, extractable nuclear antigen.
1Female/55/19957.5 mg PrednisoneArthritis3066/80.98/0.24‡372
400 mg HydroxychloroquineLivedo reticularis1/ 12800.63/<0.06
PleuritisNegative0.67/0.11
0.82/0.11
2Male/26/19845 mg PrednisoneSkin452/10.57/0.11106
250 mg ChloroquineArthritis1/800.49/0.08
1000 mg MycophenolatmofetilPleuritisNegative0.53/0.10
Renal0.55/0.10
Liver/ascites
Leucopenia
3Female/28/1993125 mg ChloroquineRaynaud’s syndrome429/71.08/0.16253
Renal1/3200.95/0.17
Skin vasculitisU1RNP0.1/0.15
Leucopenia1.04/0.17
4Female/43/19805 mg PrednisoneArthralgia6212/90.85/0.12106
50 mg AzathioprineMyalgia1/ 6400.76/0.11
RenalSS-A, SS-B0.78/0.11
Raynaud’s syndrome0.82/0.11
5Male/30/20002.5 mg PrednisoneRenal4847/90.82/0.1127
400 mg HydroxychloroquinePleuritis Arthritis1/640 Negative0.62/0.06 0.78/0.09
Cyclophosphamide IV every 3 monthsEndocarditis Leuco-lymphopenia0.77/0.10
2000 mg MesalazineFever
Colitis
6Female/38/199910 mg PrednisoneRaynaud’s syndrome279/60.83/0.1454
250 mg ChloroquineAlopecia1/6400.77/0.13
Livedo reticularisNegative0.77/0.13
Arthralgia0.82/0.15
Photosensitive rash
Neuroradiculitis