Dose-response data for prophylactic administration of drugs, expressed as a percentage change compared with baseline
| Day | NI | FCA | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Vehicle | l-NIL (mg/kg) | SC-236 (mg/kg) | l-NIL+SC -236 (mg/kg) | ||||||
| 21.5 | 43 | 86 | 2.8 | 5.6 | 11.2 | 43+5.6 | |||
| The dose-response curves were significant (p<0.001) for all measurements (see text). | |||||||||
| 1 | 6.4 (0.2) | 80.1 (15.7) | 87.7 (1.8) | 84.8 (11.1) | 95.7 (1.9) | 84.5 (1.7) | 72.7 (6.5) | 40.9 (1.2) | 72.5 (16.3) |
| 10 | 2.1 (0.5) | 56.4 (8.3) | 65.6 (1.5) | 75.7 (8.4) | 78.4 (1.9) | 56.6 (1.7) | 36.4 (12.3) | 28.0 (1.1) | 74.2 (1.1) |
| Urinary NOx | |||||||||
| 1 | −11.5 (1.9) | 487.6 (9.7) | 433.6 (1.7) | 125.2 (2.5) | 96.0 (1.3) | 434.0 (1.6) | 422.1 (14.9) | 95.4 (1.7) | 413.7 (2.0) |
| 9 | 7.5 (0.5) | 209.2 (5.2) | 77.8 (1.6) | 62.9 (9.5) | 14.8 (1.3) | 194.1 (1.1) | 200.4 (10.3) | 116.7 (1.6) | 68.1 (2.8) |
| Urinary PGE2 | |||||||||
| 1 | 3.3 (0.2) | 144.3 (7.6) | 142.9 (1.9) | 121.4 (6.6) | 101.0 (1.4) | 141.4 (1.0) | 113.2 (5.5) | 104.2 (1.3) | 115.5 (1.9) |
| 9 | −2.5 (0.5) | 45.4 (2.4) | 43.0 (1.1) | 34.4 (2.4) | 31.0 (1.2) | 41.7 (1.1) | 25.6 (2.7) | 13.2 (1.1) | 26.6 (1.3) |