Characteristics of 191 patients with rheumatoid arthritis
| Values are the mean (SD) unless stated otherwise. | |
| Positive cut off values were as follows: IgM rheumatoid factor (RF), ⩾20 IU/ml; IgA RF, ⩾7 units/ml; antiperinuclear antibodies, ⩾1:20; anti-cyclic citrullinated protein antibodies, ⩾50 units/ml; antikeratin antibodies, ⩾1:80; anticalpastatin antibodies, ⩾15 units/ml; antinuclear antibodies, ⩾1:160. | |
| Anti-CCP, anti-cyclic citrullinated protein; anti-HSP 90, anti-heat-shock protein 90 kDa antibodies; DAS, disease activity score; ESR, erythrocyte sedimentation rate; HAQ, health assessment questionnaire; RF, rheumatoid factor. | |
| †DRB1*04 includes DRB1*0401, 0404, 0405, and 0408. | |
| ‡Total damage score on radiographic evaluation of the hands and feet. | |
| Sex, % women | 73.3% |
| Age at diagnosis (years) | 50.5 (14.7) |
| Duration of disease (months) | 3.3 (2.6) |
| Morning stiffness (min) | 84 (79.4) |
| Patient’s assessment of pain (visual analogue scale) (mm) | 57.5 (22.2) |
| Swollen joints (number) | 9.0 (5.9) |
| Tender joints (number) | 21 (10) |
| Ritchie score | 17.5 (8.5) |
| HAQ score | 1.3 (0.7) |
| DAS | 4.1 (0.8) |
| Extra-articular manifestations (% patients) | 8.4% |
| ESR (mm/h) | 40.2 (28.5) |
| C reactive protein (mg/l) | 34.1 (43.2) |
| RF positivity (% patients) | 80.8% |
| IgM RF (%) | 68.0% |
| IgA RF (%) | 75.5% |
| Antibody positivity, % patients | |
| Anti-CCP | 58.9% |
| Antiperinuclear | 49.9% |
| Antikeratin | 41.4% |
| Anticalpastatin | 16.5% |
| Antinuclear | 36% |
| Anti-HSP90 | 23.0% |
| Anti-RA33 | 27.2% |
| YKL40 serum concentration (ng/ml) | 109.7 (79.9) |
| HLA-DRB1*04 (% patients)† | 47.6% |
| HLA-DRB1*01 (% patients) | 29.5% |
| Total Sharp score at baseline‡ | 3.6 (7.7) |