Table 1

Clinical information, NIRCA results, and sequencing findings in 26 patients who fulfilled the diagnostic criteria of familial Mediterranean fever

						NIRCA digestion
Patient No	Age*/sex	Age of onset (years)	FMF criteria†	Origin	Family history	Exon 10	Exon 2	Exons 3–9	Sequencing (amino acid alteration)
*Age in years corresponding to the age when genetic screening was done.
†Diagnostic criteria according to Livneh et al¹: M, major criteria; m, minor criteria.
‡ § ¶ ** ††Patients with the same symbol are relatives.
‡‡The parents of these patients were refugees from Asia Minor.
§§Overall, six asymptomatic relatives of these patients were studied.
FMF, familial Mediterranean fever; Neg, negative; NIRCA, non-isotopic RNase cleavage assay; NP, not performed; Pos, positive.
1	14 ♀	3	1M, 2m	Greek‡‡	Pos§§	Pos	Neg	Neg	M680I/V726A
2	17 ♂‡	9	2M, 1m	Greek‡‡	Neg	Pos	Neg	NP	M694V/M694V
3	15 ♀‡	4	2M, 1m	Greek‡‡	Neg	Pos	Neg	Neg	M694V/M694V
4	32 ♀	10	2M, 2m	Greek‡‡	Neg	Pos	Pos	Pos	M694V/0, D102D/D102D, G138G/G138G, A165A/A165A, G219G/0, R314R/0, E474E/0, D510D/0
5	40 ♀§	8	2M, 2m	Greek‡‡	Neg	Pos	Neg	NP	M694V/M694I
6	38 ♀§	12	2M, 2m	Greek‡‡	Neg	Pos	Neg	Neg	M694V/M694I
7	31 ♀	9	2M, 1m	Greek	Neg§§	Pos	Neg	Neg	M680I/M694V
8	7 ♂	6	1M, 1m	Greek	Neg	Pos	Neg	Neg	V726A/0
9	28 ♂	14	2M	Greek	Neg	Pos	Neg	Neg	M694V/0
10	27 ♂	24	1M, 2m	Greek‡‡	Neg	Neg	Neg	Neg	Absence of alterations
11	45 ♂	5	2M, 1m	Jewish	Neg§§	Pos	Neg	Neg	M694V/M694V
12	12 ♀¶	4	2M, 1m	Jewish	Pos	Pos	Neg	Neg	M694V/M694V
13	16 ♂¶	9	2M, 1m	Jewish	Pos	Pos	Neg	NP	M694V/R761H
14	17 ♀	3	2M, 1m	Armenian	Neg	Neg	Pos	Pos	R202Q/R202Q, D102D/D102D, G138G/G138G, A165A/A165A R314R/0, E474E/0, Q476Q/0, D510D/0
15	5 ♀	4	2M, 1m	Greek	Neg	Neg	Pos	Neg	R202Q/R202Q, D102D/D102D, G138G/G138G, A165A/A165A
16	26 ♀	12	2M, 1m	Greek	Neg	Neg	Pos	Neg	R202Q/R202Q, D102D/D102D
17	18 ♀	8	1M, 2m	Greek	Neg	Neg	Pos	Neg	E148Q/E148Q
18	4 ♂**	3	1M, 2m	Greek‡‡	Pos	Pos	Pos	NP	M680I/0, E167D/0, D102D/0
19	28 ♀**	12	2M	Greek‡‡	Neg	Pos	Pos	Neg	M680I/0, E167D/0, D102D/0, R202Q/0
20	22 ♀††	4	2M, 1m	Greek‡‡	Pos	Pos	Neg	NP	M680I/M694V
21	18 ♀††	8	1M, 2m	Greek‡‡	Pos	Pos	Neg	NP	M680I/M694V
22	55 ♂††	12	3m	Greek‡‡	Neg	Pos	Neg	Neg	M694V/0
23	24 ♂	10	2M, 1m	Greek‡‡	Neg	Pos	Neg	Neg	M680I/V726A
24	17 ♀	12	2M	Greek	Neg	Pos	Neg	Neg	M680I/M694V
25	20 ♂	14	2M, 1m	Greek	Neg	Neg	Pos	Neg	R202Q/R202Q, D102D/D102D, G138G/G138G, A165A/A165A
26	19 ♂	12	2M	Greek	Neg	Pos	Pos	Neg	M694V/0, R202Q/0