Clinical and laboratory data of the patients with SpA and CD at baseline and during treatment with infliximab or various other conventional treatments (oral azathioprine 100 mg daily, topical and systemic salicylates, topical and systemic steroids, antibiotics, metronidazole)
| Infliximab | Controls† | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T0 | T45 | T3M | T6M | T12M | T18M | T0 | T45 | T3M | T6M | T12 | |
| Results are presented as the mean (SD) unless stated otherwise. Comparison between baseline and subsequent assessments was performed with Wilcoxon’s matched pairs signed rank test: *p<0.05; ** = p<0.01. | |||||||||||
| †All the patients in the control group had active CD at baseline; ‡withdrawal due to side effects or inefficacy. | |||||||||||
| Number of patients | 24 | 24 | 24 | 23 | 22 | 12 | 12 | 12 | 12 | 12 | 8 |
| Withdrawals‡ | – | 0 | 0 | 1 | 2 | 0 | – | 0 | 0 | 0 | 4 |
| CDAI (total group) | 252 (119.5) | 144 (47.0)* | 125 (30.1)** | 135 (78.2)** | 110 (27.3)** | 128 (19.7)** | – | – | – | – | – |
| CDAI (active CD at baseline) | 308 (90.3) | 154 (42.5)* | 137 (29.5) | 151 (79.1)** | 137 (31.3)** | 136 (18.7)** | 285 (70.6) | 163 (29.2)** | 139 (27.1)** | 113 (29.2)** | 125 (26.5)** |
| CDAI (inactive CD at baseline) | 118 (23.2) | 96 (17.5) | 99 (13.1) | 89 (8.7) | 90 (17.2)* | 92 (19.4) | – | – | – | – | – |
| ESR (mm/1st h) | 38.5 (23.7) | 20.0 (13.2)* | 14.4 (7.6)** | 17.2 (13.7)** | 12.8 (9.3)** | 14.3 (8.5)** | 35.1 (17.1) | 21.42 (10.7)* | 19.1 (8.3)** | 13.9 (6.6)** | 17.6 (7.9)** |
| CRP (mg/l) | 36 (25) | 11 (8)** | 8 (5.4)** | 11 (7)** | 7 (3)** | 8 (3)** | 32 (24) | 17 (9)* | 14 (10)* | 8 (4)** | 7 (5)** |
| Musculoskeletal pain (VAS) | 63.8 (15.6) | 16.8 (9.6)** | 17.2 (10.2)** | 23 (17.6)** | 18.2 (7)** | 18.9 (9.1)** | 65.6 (10.7) | 42.6 (16.7)* | 42.8 (14.6)* | 46.5 (22.4)* | 38.6 (22.7)* |
| BASDAI | 64.2 (12.2) | 25.7 (12.2)** | 24.0 (10.1)** | 26.5 (15.3)** | 18.1 (8.3)** | 20.0 (9.9)** | 56.7 (13.8) | 47.3 (11.8) | 44.7 (11.6* | 43.65 (16.1)* | 40.05 (18.2)* |
| Axial pain (VAS) | 60.8 (24.6) | 17.3 (11.9)** | 17.0 (8.8)** | 19.8 (17.3)** | 17.4 (8.1)** | 19.6 (16.3)** | 61.8 (21.4) | 48.18 (19.9) | 44.3 (18.7)* | 43.0 (22.9)* | 37.8 (23.3)* |
| Peripheral arthritis (yes/no) | 14/10 | 4/20 | 3/21 | 3/20 | 1/17 | 2/10 | 9/3 | 5/7 | 5/7 | 2/10 | 1/7 |
| Active enthesitis (yes/no) | 15/9 | 6/18 | 5/19 | 5/18 | 2/16 | 2/10 | 10/2 | 9/3 | 6/6 | 7/5 | 4/4 |