MFI values for the factors of anabolic and catabolic pathways affecting ECM homoeostasis and CAM macromolecules
| Hydrocortisone (µg/ml) | ||||
|---|---|---|---|---|
| 0.00 | 0.05 | 0.20 | 1.00 | |
| Median MFI values, lower and upper ranges are given for the different variables under the influence of 0.00, 0.05, 0.20, and 1.00 µg of hydrocortisone per ml of nutrient medium. | ||||
| *Wilcoxon rank sum test for paired samples, significant change compared with control, p<0.05. | ||||
| IGF-1 | 55.2 (35.4–61.9) | 55.2 (35.4–61.1) | 55.5 (35.1–61.3) | 55.3 (35.7–61.6)* |
| IGFR1 | 11.4 (8.2–12.9) | 14.7 (9.6–16.7)* | 15.6 (10.0–17.3)* | 15.8 (10.6–18.3)* |
| IL1RII | 11.1 (8.5–17.5) | 13.2 (10.9–18.7)* | 14.9 (11.4–19.9)* | 15.6 (12.4–20.1)* |
| IL1α | 34.9 (23.6–72.6) | 24.2 (21.4–63.9)* | 21.8 (20.3–62.9)* | 20.4 (19.9–61.8)* |
| IL1β | 78.5 (45.1–81.9) | 65.1 (38.4–68.7)* | 54.0 (35.5–64.5)* | 53.1 (36.3–61.7)* |
| IL1RI | 11.7 (9.4–15.4) | 10.9 (9.2–15.0)* | 10.8 (8.5–14.7)* | 10.2 (8.0–14.1)* |
| Aggrecan | 41.8 (28.3–57.9) | 96.3 (41.8–118.8)* | 114.9 (53.0–180.1)* | 118.8 (61.1–187.9)* |
| Collagen | 15.7 (12.0–24.6) | 19.8 (15.3–30.0)* | 20.0 (17.4–32.9)* | 26.9 (17.9–34.6)* |
| Fibronectin | 221.5 (193.8–522.2) | 363.7 (252.3–633.7)* | 454.1 (261.9–84.9)* | 545.8 (304.8–793.1)* |