IL1Ra secretion by OA articular chondrocytes
| Samples | Condition | IL1Ra (% of maximum) |
|---|---|---|
| *IL1Ra secretion in primary cells from three different donors, stimulated with 2500 U/ml IFNβ and 1 ng/ml IL1β, ranged from 360.1 to 573.1 ng/ml (mean (SEM) 488.5 (65.3)); †IL1Ra secretion in dedifferentiated cells (passages 4–6, five different donors) stimulated with 2500 U/ml IFNβ and 1 ng/ml IL1β ranged from 369.2 to 1573.7 ng/ml (mean (SEM) 771.4 (218.8)); ‡p<0.05 v control; §p<0.01 v IL1β or IFNβ alone. | ||
| OA knee (n = 3) | Control | 3.09 (3.09) |
| Primary cells | IFNβ 2500 U/ml | 4.72 (3.64) |
| IL1β 1 ng/ml | 18.11 (7.71) | |
| IFNβ and IL1β* | 100 (0)‡ § | |
| OA femoral head (n = 5) | Control | 1.49 (1.24) |
| Dedifferentiated cells | IFNβ | 2.31 (2.31) |
| IL1β | 18.77 (5.62)‡ | |
| IFNβ and IL1β† | 100 (0)‡ § | |