Table 1

Frequencies of all defined HLA-DR-DQ haplotypes in 322 patients with rheumatoid arthritis and 622 affected family based artificial controls, and their classification into haplotype risk groups

Haplotype risk group	DRB1-DQA1-DQB1 haplotype	Patients (n = 644 haplotypes)		Controls (AFBAC) (n = 1244 haplotypes)		OR	95% CI	p Value*
Haplotype risk group	DRB1-DQA1-DQB1 haplotype	N	%	N	%	OR	95% CI	p Value*
*Only statistically significant p values are shown.
†By Fisher’s exact test.
AFBAC, affected family based artificial controls; CI, confidence interval; N, neutral; O, other; OR, odds ratio; P, strongly protective; p, weakly protective; S, Strong susceptibility; s, weak susceptibility.
Susceptibility haplotypes
S	0401-(03)-0301	51	7.9	14	1.1	7.56	4.02 to 14.42	<10⁻⁶
S	0408-(03)-0301	17	2.6	6	0.5	5.59	2.07 to 15.93	0.00013
S	0401-(03)-0302	109	16.9	81	6.5	2.93	2.13 to 4.02	<10⁻⁶
S	0404-(03)-0302	41	6.4	41	3.3	2.00	1.25 to 3.18	0.0028
s	(01/10)-(01)-0501	162	25.2	225	18.1	1.52	1.20 to 1.93	0.00039
Neutral haplotypes
N	0407-(03)-0301	2	0.3	3	0.2	1.29	0.10 to 9.45
N	(03)-05-02	37	5.7	95	7.6	0.74	0.49 to 1.11
N	(07)-0201-02	19	3.0	51	4.1	0.71	0.40 to 1.25
N	(09)-03-0303	18	2.8	52	4.2	0.66	0.37 to 1.17
Protective haplotypes
p	(15)-(01)-0602	65	10.1	200	16.1	0.59	0.43 to 0.80	0.00050
p	(08)-(04)-04	39	6.1	125	10.0	0.58	0.39 to 0.85	0.0046
p	(11/12)-05-0301	35	5.4	114	9.2	0.57	0.38 to 0.86	0.0058
P	(1302)-(01)-0604	9	1.4	42	3.4	0.41	0.18 to 0.87	0.018
P	(1301)-(01)-0603	21	3.3	109	8.8	0.35	0.21 to 0.58	0.000012
P	(07)-0201-0303	4	0.6	31	2.5	0.24	0.09 to 0.73	0.0020†
P	(16)-(01)-0502	1	0.2	11	0.9	0.17	0.02 to 1.30	0.048†
Other haplotypes
O	0403-(03)-0302	7	1.1	7	0.6	1.94	0.61 to 6.17
O	(09)-03-02	0	0	1	0.1	0.64
O	(14)-(01)-0503	6	0.9	26	2.1	0.44	0.16 to 1.13
O	0403-(03)-0304	0	0	2	0.2	0.39
O	x-03-0301	1	0.2	8	0.6	0.24	0.02 to 2.21