Table 1

Clinical features and endoscopic findings in patients with RA and in control subjects

Patient	Age (years)	Duration of RA (years)	Treatment DMARDs/PRED	Gastroscopy		Histological findings
Patient	Age (years)	Duration of RA (years)	Treatment DMARDs/PRED	Indication	Endoscopic findings	Stomach	Duodenum
RA, rheumatoid arthritis; CTRL, control subject; DMARD, disease modifying antirheumatic drug; PRED, prednisone; MTX, methotrexate; SSZ, sulfasalazine; HCQ, hydroxychloroquine; LEF, leflunomide; Hp+, Helicobacter pylori positive at histology.
RA1	75	28	MTX+SSZ/−	Anaemia	Mild gastritis	Mild chronic inflammation (antrum, corpus)	Normal
RA2	80	25	MTX/+	GERD	Oesophagitis, gastric atrophy	Mild chronic inflammation (corpus), mild oesophagitis	Normal
RA3	83	50	−/+	Heartburn, abdominal pain	Gastric atrophy, antral intestinal metaplasia	Atrophy and intestinal metaplasia in antrum	Normal
RA4	63	17	LEF/−	Abdominal pain	Large prepyloric ulcer	Normal	Normal
RA5	43	2	MTX/−	Anaemia	Normal	Normal	Normal
RA6	56	15	MTX/+	Abdominal pain	Gastric atrophy	Mild chronic inflammation (antrum, corpus)	Mild chronic inflammation
RA7	55	7	MTX/+	Abdominal pain	Duodenogastric reflux	Mild chronic inflammation (corpus)	Normal
RA8	50	10	LEF/+	Anaemia	Hiatus hernia	Normal	Normal
RA9	56	14	MTX+SSZ/+	Abdominal pain, vomiting	Normal	Normal	Normal
RA10	47	24	−/−	Abdominal pain	Mild antrum gastritis	Mild chronic inflammation (corpus)	Normal
RA11	42	<1	−/−	Diarrhoea	Normal	Normal	Normal
RA12	39	4	SSZ+HCQ/−	Abdominal pain, anaemia	Mild corpus gastritis	Intestinal metaplasia, atrophy in corpus, mild chronic inflammation (corpus, antrum)	Normal
RA13	84	4	HCQ/+	Anaemia	Angular ulcer	Severe chronic inflammation (angulus), severe intestinal metaplasia and atrophy in antrum	Normal
CTRL1	39			Abdominal pain	Normal	Normal	Normal
CTRL2	53			Barrett’s oesophagus (control)	Barrett’s oesophagus	Mild chronic inflammation (antrum), severe intestinal metaplasia in oesophagus	Normal
CTRL3	43			Heartburn	Mild chronic gastritis	Mild chronic gastritis (antrum, corpus, angulus), Hp+, mild intestinal metaplasia and atrophy in corpus	Normal
CTRL4	70			Barrett’s oesophagus (control)	Normal	Normal	Normal
CTRL5	65			Barrett’s oesophagus (control)	Barrett’s oesophagus	Mild chronic inflammation (corpus) with intestinal metaplasia in antrum and oesophagus	Not examined
CTRL6	39			Diarrhoea	Normal	Normal	Normal
CTRL7	53			Hypoalbuminaemia	Erosions in antrum, corpus	Moderate chronic inflammation (antrum, corpus), Hp+	Normal
CTRL8	56			Reflux (control)	Haematomatous cystic polyps in corpus	Normal	Normal
CTRL9	52			Barrett’s oesophagus (control)	Barrett’s oesophagus, hiatus hernia	Gastric biopsies not taken; severe intestinal metaplasia in oesophagus	Not examined
CTRL10	76			Pyloric ulcer (control)	Deformed pylorus, no ulcer	Mild chronic inflammation (corpus), with intestinal metaplasia	Not examined
CTRL11	36			Suspected submucous tumour (control)	Normal	Mild intestinal metaplasia (antrum)	Normal
CTRL12	30			Abdominal discomfort	Normal	Normal	Normal
CTRL13	75			Problems in swallowing	Hiatus hernia	Normal	Normal
CTRL14	30			Abdominal pain	Suspected antral polyps	Normal	Normal
CTRL15	38			Heartburn	Oesophagitis	Gastric histology normal, candida oesophagitis	Normal