Genes down regulated more than threefold in early RA
| Category | Gene identifier | Chromosome location | Description |
|---|---|---|---|
| Immune/inflammatory | CCR1 | 3p21.31 | Chemokine receptor (c-c motif) |
| PTGES | 9q34.11 | Prostaglandin E synthase | |
| LMAN1 | 18q21.3–22 | Mannose binding lectin 1 | |
| NSEP1 | 1p34 | Nuclease sensitive element binding protein | |
| FKPB1A | 20p13 | FK506 binding protein 1A | |
| IFI30 | 19p13.1 | IFNγ inducible protein 30 | |
| HLA-DP1A | 6p21.3 | MHC class II DP α1 | |
| B2M | 15q21–22.2 | β2-Microglobulin; MHC class I | |
| FYB | 5p14.1 | FYN binding protein; T cell signalling | |
| HLA-DR4A | 6p21.3 | MHC class II DRα | |
| Cancer/neoplasia | SAT | Xp22.1 | Spermidine/spermine N1-acetyltransferase; carcinogenesis |
| RAB7 | 3q22.1 | RAS oncogene family | |
| SSX3 | Xp11.2-11.1 | Synovial sarcoma breakpoint 3 | |
| LAMR1 | 3p21.3 | Laminin receptor expressed in colon carcinoma | |
| M17S2 | 17q21.31 | Ovarian carcinoma antigen (CA-125) | |
| PTPRA | 20p13 | Protein tyrosine phosphatase; neoplastic transformation | |
| SAS | 12q13–14 | Sarcoma amplified sequence | |
| LCP1 | 19p13.3 | l-Plastin; related to colon cancer metastasis | |
| LRP8 | 17q11–21.3 | LIM and SHE protein-1 (LASP-1) | |
| S100A10 | 1q21 | S100 calcium binding protein | |
| Transcription/translation/cell cycle | CAP ARPC5 | 1p34.2 1q25.3 | Adenylyl cyclase associated protein Actin related protein subunit 5 |
| ARHGDIB | 12q12.3 | Rho GDP dissociation inhibitor | |
| ARPC3 | 12q24 | Actin related protein subunit 3 | |
| HIF1A | 14q21–24 | Hypoxia inducible factor | |
| CHES1 | 14q32.11 | Checkpoint suppressor 1 | |
| Growth factors | SNX2 | 5q23 | Sorting nexin 2; EGF receptor pathway |
| ZFP364 | 14q22–24 | EGF response factor 1 | |
| LTBP1 | 2p21–22 | Latent TGFβ binding protein 1 | |
| Metabolism | OAZ1 | 2p25 | Ornithine decarboxylase antizyme 1 |
| CYP24 | 20q13.2–13.3 | Cytochrome P450 subfamily 24 | |
| POR | 7q11.23 | P450 cytochrome oxidoreductase | |
| METTL1 | 12q13 | Methyltransferase-like 1 | |
| Cartilage/bone | CHI3L1 | 1q31.1 | Chitinase 3-like (cartilage glycoprotein-39) |
| BMP4 | 14q22–23 | Bone morphogenetic protein 4 |