Change in markers of endothelial activation following peripheral cold challenge
| Vasoactive peptide | Baseline | Reference range* | Post cold challenge | p Value (paired t test) |
|---|---|---|---|---|
| Values are mean (SD) and range. | ||||
| *Reference ranges derived from control patients with systemic sclerosis and no pulmonary artery hypertension. Samples taken from peripheral vein in control patients. | ||||
| vWF, von Willebrand factor. | ||||
| Endothelin-1 (fmol/ml) | 1.87 (0.13) | 0.18 to 1.52 | 1.83 (0.11) | 0.4 |
| vWF (IU/dl) | 245 (39) | 23 to 177 | 253 (42) | 0.4 |
| Fibrinogen (μmol/l) | 3.15 (0.45) | 1 to 2.18 | 3.54 (0.63) | 0.5 |
| 3-Nitrotyrosine (nM) | 610 (80) | 200 to 1500 | 548 (73) | 0.6 |