Table 1

The rate of apoptosis (TUNEL positive) of lymphocytes, expression of CD95, and serum levels of sFAS and IL15 in children with JIA according to the type of onset and activity of the disease. Correlation between examined parameters and acute phase indicators

Examined groupsNoTUNEL (% cells) Mean (SD)CD95 (% cells) Mean (SD)sFAS (pg/ml) Mean (SD)IL15 (pg/ml) Mean (SD)
*Significant.
CRP, C reactive protein; ESR, erythrocyte sedimentation rate; rs, Spearman rank coefficient.
Controls302.3 (2.9)9.8 (5.5)5024.5 (2184.5)1.7 (0.6)
JIA - whole group446.5 (7.4)12.1 (7.3)5761.3 (2856.1)1.9 (1.3)
Type of onset
    Oligoarthritis103.7 (3.9)11.2 (9.4)6308.0 (3512.1)1.0 (0.4)
    Polyarthritis244.8 (7.1)13.1 (7.2)5661.0 (2427.2)1.1 (0.6)
    Systemic1013.5 (7.1)9.7 (3.8)5502.9 (3557.6)3.6 (2.1)
Activity of the disease
    Low112.7 (2.5)13.2 (13.2)6894.0 (2736.1)1.6 (0.1)
    Moderate154.9 (8.1)10.9 (6.9)5492.5 (2345.1)1.8 (1.4)
    High189.2 (8.0)12.6 (5.5)5455.0 (3196.0)2.3 (1.6)
Statistics (p values)
    Control v JIA0.020*0.3310.4240.825
    Control v oligoarthritis0.3810.8590.3510.046*
    Control v polyarthritis0.1230.2060.4110.950
    Control v systemic disease0.001*0.7800.8670.012*
    Control v low activity0.4370.9380.0710.612
    Control v moderate activity0.5170.5960.4960.517
    Control v high activity0.001*0.1950.8780.203
Acute phase indicatorsv TdTv CD95v sFASv IL15
    Lymphocyte count0.098, rs=0.3130.368, rs=−0.1960.038*, rs=−0.3130.867, rs=−0.035
    Platelet count0.495, rs=−0.1370.068, rs=0.4040.438, rs=−0.1220.543, rs=−0.133
    CRP0.017*, rs=0.4600.469, rs=−0.1660.172, rs=−0.2250.039*, rs=0.442
    ESR0.005*, rs=0.5020.867, rs=0.0360.114, rs=−0.2410.089, rs=0.347