Data on synovial tissue analysis before (mean (SEM)) and after (mean (SEM)) treatment and the percentage change (mean (SEM)) in the placebo group and the CCR1 antagonist treated group compared with baseline. Data represent total cell count in 18 high power fields corrected for the percentage of actual tissue in the analysed areas for cellularity, CD68+ macrophages, CD4+ lymphocytes, CD8+ lymphocytes, CCR1+ cells, CD22+ lymphocytes, CD55+ fibroblasts, and CD138+ plasma cells
| Placebo (n=4) | CCR1 antagonist (n=12) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Before Mean (SEM) | After Mean (SEM) | % Mean (SEM) | p Value* | Before Mean (SEM) | After Mean (SEM) | % Mean (SEM) | p Value* | p Value† | |
| *Represents p value according to the paired t test for comparison of cell count between baseline and end of study in each group; †represents p value according to the two sample t test for comparison of the percentage change from baseline between the groups. | |||||||||
| Overall cellularity | 2308 (416) | 1741 (414) | −25 (9) | NS | 1795 (423) | 967 (164) | −46 (8) | 0.013 | NS |
| Intimal lining cellularity | 553 (141) | 401 (79) | −27 (14) | NS | 423 (95) | 209 (49) | −51 (22) | 0.048 | NS |
| Overall CD68+ macrophages | 1915 (335) | 2200 (331) | 15 (5) | NS | 2427 (261) | 1593 (283) | −34 (4) | 0.004 | 0.016 |
| Intimal lining CD68+ macrophages | 900 (201) | 1151 (284) | 28 (13) | NS | 1155 (130) | 677 (133) | −41 (5) | 0.021 | 0.026 |
| CD4+ Lymphocytes | 583 (236) | 563 (186) | −3 (28) | NS | 666 (159) | 358 (139) | −46 (24) | 0.023 | NS |
| CD8+ Lymphocytes | 175 (96) | 153 (25) | −13 (41) | NS | 157 (44) | 84 (31) | −47 (32) | 0.024 | NS |
| CCR1+ Cells | 967 (255) | 1305 (124) | 35 (5) | NS | 1125 (345) | 379 (108) | −66 (84) | 0.074 | 0.049 |
| CD22+ Lymphocytes | 630 (399) | 668 (184) | 6 (44) | NS | 191 (77) | 206 (72) | 8 (28) | NS | NS |
| CD55+ Fibroblasts | 1374 (276) | 978 (115) | −29 (9) | NS | 1710 (153) | 1201 (218) | −30 (3) | NS | NS |
| CD138+ Plasma cells | 265 (150) | 532 (416) | 101 (255) | NS | 129 (79) | 232 (127) | 80 (108) | NS | NS |