Actions of lipoxins on human leucocytes
| Lipoxin | Leucocytes | Action |
|---|---|---|
| LXA4 | PMN | Blocking of emigration, transmission, and chemotaxis |
| Down regulation of CD 11/18, IP3, Ca2+ | ||
| Inhibition of PMN-endothelial cells and epithelial cell interactions | ||
| Eosinophils | Inhibition of chemotaxis (PAF, FMLP) | |
| NK cells | Inhibition of cytotoxicity | |
| Monocytes | Stimulation of chemotaxis and adherence | |
| Stimulation of myeloid progenitors | ||
| LXB4 | PMN | Blocking of emigration, transmission, and chemotaxis |
| Down regulation of CD 11/18, IP3, Ca2+ | ||
| Inhibition of PMN-endothelial cells and epithelial cell interactions | ||
| NK cells | Inhibition of cytotoxicity | |
| Monocytes | Stimulation of chemotaxis and adherence | |
| Stimulation of myeloid progenitors |