Table 1

Effects of blocking TNF or LT during experimental mycobacterial infections in mice

Mycobacterial strainExperimental systemEffect on antibacterial protectionEffect on granuloma developmentReference
LT, lymphotoxin; tmTNF, transmembrane TNF; sTNF, soluble TNF; KO, knockout; TG, transgenic; IgGFc, fusion protein; CFU colony forming units.
M tuberculosis TNF-KOIncreased CFUDelayed formation 23
M tuberculosis TNFRp55-KOIncreased CFUDelayed formation, necrosis 26
M bovis BCG, M tuberculosistmTNF-TGNo or slightly increased CFUNone or marginal 37
M tuberculosis anti-TNF mAb in chronic phaseIncreased CFUDisorganisation, diffuse infiltration 28
M bovis BCGanti-TNF mAbIncreased CFUMalformation, breakdown 27
M tuberculosis, M bovis BCGsTNFRp55-TGIncreased CFUNecrosis 56
M avium TNFRp55-KONo or marginally increased CFUDisintegration, disorganised mixed infiltrate22, 25
M tuberculosis LTα-KOIncreased CFUDelayed formation, structural defects 35
M tuberculosis LTβR-KO, LTβ-KOIncreased CFUDelayed formation, delayed macrophage activation 36
M bovis BCGLTβR-IgGFcIncreased CFUMarginal 57
M bovis BCGTNF-LTα-KOIncreased CFUDiffuse infiltrations 58