Autoantibody (method) | Positive | SLE | Sensitivity | Specificity | PPV | NPV |
---|---|---|---|---|---|---|
ANA, antinuclear antibodies; anti-dsDNA, anti-double-stranded DNA; IF, immunofluorescence; NPV, negative predictive value; PPV, positive predictive value; SLE, systemic lupus erythematosus. | ||||||
Anti-telomere | 176/379 (46%) | 164/275 | 60% | 91% | 95% | 46% |
Anti-dsDNA (Shield) | 185/330 (56%) | 142/205 | 69% | 66% | 77% | 57% |
Anti-dsDNA (Inova) | 87/404 (22%) | 82/279 | 29% | 96% | 94% | 38% |
Chrithidia luciliae (IF) | 39/422 (9%) | 38/298 | 13% | 99% | 97% | 32% |
ANA (IF) | 296/423 (70%) | 227/298 | 76% | 45% | 77% | 44% |
Best combinations of two assays | ||||||
Anti-telomere+anti-dsDNA (Shield) | 174/287 (61%) | 140/183 | 77% | 67% | 80% | 62% |
Anti-telomere+ANA | 290/377 (77%) | 235/273 | 86% | 47% | 81% | 56% |
Anti-dsDNA (Shield)+ANA | 259/331 (78%) | 181/206 | 88% | 38% | 70% | 65% |