Side effects | No of patients | Mean (SD) | p Value | |
---|---|---|---|---|
No significant difference between patients with or without side effects in folic acid consumption, serum folic acid, plasma homocysteine, or methotrexate dose (t test). | ||||
*Data available from only 72 participants. | ||||
†Data available from only 77 participants. | ||||
Folate supplementation (mg/week) | No | 60 | 5.30 (8.44) | 0.733 |
Yes | 33 | 5.93 (9.19) | ||
Serum folate (ng/ml)* | No | 45 | 9.11 (5.41) | 0.965 |
Yes | 27 | 9.05 (6.54) | ||
Plasma homocysteine (μmol/l)† | No | 49 | 13.31 (4.27) | 0.697 |
Yes | 28 | 12.88 (5.07) | ||
Methotrexate dose (mg/week) | No | 60 | 11.91 (3.77) | 0.800 |
Yes | 33 | 11.99 (3.42) |