Anti-CCP, IgM RF, IgA RF, IgG RF, APF and AKA levels and status measured at the beginning of the study in patients designated as fast progressors (Larsen score progression >10) and slow progressors (Larsen score <10) after two years of follow up. Results are shown as No (%) unless otherwise stated
| Fast progressors (n=36) | Slow progressors (n=68) | Significance | OR (95% CI) | |
|---|---|---|---|---|
| Anti-CCP+ | 24 (67) | 20 (29) | <0.001 | 4.8 (2.0 to 11.4) |
| IgM RF+ | 23 (64) | 27 (40) | 0.024 | 2.7 (1.2 to 6.2) |
| IgA RF+ | 19 (53) | 20 (29) | 0.032 | 2.7 (1.2 to 6.2) |
| IgG RF+ | 19 (53) | 19 (28) | 0.018 | 2.9 (1.2 to 6.7) |
| APF+ | 18 (5) | 20 (29) | 0.054 | 2.4 (1.0 to 5.5) |
| AKA+ | 23 (64) | 16 (24) | <0.001 | 5.2 (2.2 to 12.5) |
| Anti-CCP+ and IgM RF+ | 18 (50) | 12 (18) | 0.001 | 4.7 (1.9 to 11.5) |
| Anti-CCP+ and/or IgM RF+ | 29 (81) | 35 (51) | 0.006 | 3.9 (1.5 to 10.1) |
| Anti-CCP (units), mean (SD) | 240.0 (258) | 88.3 (159) | <0.001 | – |
| IgM RF (index), mean (SD) | 3.3 (2.6) | 2.6 (2.7) | 0.035 | – |
| IgA RF (index), mean (SD) | 2.8 (2.4) | 2.4 (2.8) | 0.032 | – |
| IgG RF (index), mean (SD) | 3.2 (2.9) | 2.4 (2.8) | 0.034 | – |