Frequency of gene polymorphisms in patients with RA treated with etanercept (Enbrel)
| Gene, polymorphism | Non-responders No (%) | Responders No (%) | p Value |
|---|---|---|---|
| TNFA, −308 | |||
| TNF1/TNF1 | 12 (50) | 65 (66) | |
| TNF1/TNF2 | 11 (46) | 32 (32) | |
| TNF2/TNF2 | 1 (4) | 2 (2) | 0.33 |
| IL10, −1087 | |||
| G/G | 8 (33) | 27 (27) | |
| A/G | 13 (54) | 42 (43) | |
| A/A | 3 (13) | 30 (30) | 0.22 |
| TGFB1, codon 25 | |||
| G/G | 20 (83) | 84 (85) | |
| G/C | 4 (17) | 15 (15) | 1.00 |
| IL1RN, intron 2 VNTR | |||
| A1/A1 | 13 (54) | 69 (70) | |
| A1/A2 | 8 (33) | 22 (22) | |
| A2/A2 | 1 (4) | 6 (6) | |
| A1/A4 | 1 (4) | 0 | |
| A2/A4 | 1 (4) | 2 (2) | |