Cytokine gene polymorphisms with pro- and anti-inflammatory potential
| Gene symbol | Polymorphism position | Alleles | Functional role |
|---|---|---|---|
| TNFA | −308 | G=TNF1 | Normal production of TNF |
| A=TNF2 | Up regulation of TNF production in different type of cells[22] [24] | ||
| IL10 | −1087 | G | GG genotype associates with up regulation of IL10 production in lymphocytes |
| A | AA genotype associates with down regulation of IL10 production in lymphocytes[23] | ||
| TGFB1 | +915, codon 25 | G | Normal production of TGFβ1 |
| C | Down regulation of secretion of TGFβ1 from the peripheral blood leucocytes[21] | ||
| IL1RN | Intron 2 | A1=4 repeats | “Normal” allele[25] |
| A2=2 repeats | Up regulation of IL1Ra production in sera and down regulation in saliva[19] |