Laboratory variables measured in patients with rheumatoid vasculitis (HRV) and in patients with rheumatoid arthritis with EAMs, but no histological evidence of vasculitis (RA+EAM). Results are shown as No (%)
| HRV (n=31) | RA+EAM (n=50) | Odds ratio (95 CI) | p Value | |
|---|---|---|---|---|
| Where appropriate, thresholds were determined such that 95% of the “RA−” control group was normal, except for C3, IgA RF, and ESR. For these parameters thresholds were determined by ROC analysis of the “HRV” versus “RA+EAM” groups. | ||||
| *p Value of Fisher’s exact test. | ||||
| CICs >52 μgEq/ml | 16 (55) | 11 (22) | 4.3 (1.6 to 11.5) | 0.006 |
| C3 <0.7 g/l | 19 (66) | 9 (18) | 8.4 (2.9 to 24.2) | <0.0001 |
| C4 <0.2 g/l | 10 (35) | 12 (25) | 1.6 (0.6 to 4.4) | 0.44 |
| vWF >3.75 IU/ml | 8 (35) | 1 (2) | 22.4 (2.6 to 194) | 0.001 |
| AEA >33 U/ml | 7 (26) | 13 (26) | 1.0 (0.3 to 2.9) | 0.99 |
| ANCA | ||||
| Cytoplasmatic | 0 | 1 (2) | – | 0.99 |
| Perinuclear | 13 (48) | 15 (30) | 2.1 (0.8 to 5.5) | 0.21 |
| Non-specific | 0 | 0 | – | – |
| Absent | 14 (52) | 34 (68) | 1.0 (–) | 0.21 |
| Anti-PR3 ⩾0.8 U/ml | 1 (4) | 2 (4) | 0.9 (0.1 to 11.7) | 0.99 |
| Anti-MPO >30 U/ml | 3 (11) | 4 (8) | 1.4 (0.3 to 7.0) | 0.69 |
| Antilactoferrin >25 U/ml | 2 (7) | 3 (6) | 1.3 (0.2 to 8.0) | 0.99 |
| ICAM-1 >720 ng/ml | 0 (0) | 1 (2) | 0 (–) | 0.99 |
| ICAM-3 >90 ng/ml | 15 (54) | 35 (71) | 0.5 (0.2 to 1.2) | 0.14 |
| VCAM >1200 ng/ml | 8 (29) | 8 (16) | 2.1 (0.7 to 6.3) | 0.25 |
| E-selectin >115 ng/ml | 5 (18) | 17 (35) | 0.4 (0.1 to 1.3) | 0.19 |
| Cellular fibronectin >400% | 18 (62) | 13 (26) | 4.7 (1.7 to 12.4) | 0.002 |
| IgM RF >265 U/ml | 11 (37) | 9 (18) | 2.6 (0.9 to 7.4) | 0.10 |
| IgG RF >550 U/ml | 13 (43) | 7 (14) | 4.7 (1.6 to 13.8) | 0.007 |
| IgA RF >14 U/ml | 19 (63) | 10 (20) | 6.9 (2.5 to 19.1) | <0.0001 |
| ANA positive | 13 (42) | 20 (40) | 1.1 (0.5 to 2.9) | 0.82 |
| ESR >59 mm/1st h | 26 (84) | 27 (54) | 4.4 (1.5 to 13.4) | 0.008 |
| CRP >104.5 mg/l | 2 (7) | 10 (20) | 0.3 (0.1 to 1.5) | 0.19 |