Mean (SD) and confidence interval of free, peptide bound, and total PYD, DPD, and PYD/DPD by HPLC and Ntx by immunoassay in RA, PsA, OA, HA, and HC groups
| RA | PsA | OA | HA | HC | |
|---|---|---|---|---|---|
| f, free; p, peptide bound; t, total, measured by HPLC | |||||
| The crosslinks were expressed as nmol/mmol creatinine (Cr), except for the qotients of the crosslinks. The values in brackets are the 95% confidence intervals. | |||||
| All measurements showed a significant difference among the groups as calculated by the Kruskal-Wallis test. | |||||
| A significance between two groups was determined by the Mann-Whitney U test; significances are reported in the text. | |||||
| Number | 50 | 46 | 38 | 33 | 17 |
| fPYD (nmol/mmol Cr) | 34.9 (23.6) | 16.6 (7.6) | 15.8 (7.0) | 16.0 (6.6) | 116 (30) |
| (6.8 to 100) | (8.9 to 41) | (5.0 to 36.3) | (7.9 to 35.2) | (51 to 156) | |
| pPYD (nmol/mmol Cr) | 44.9 (29.7) | 24.5 (15.9) | 19.3 (7.4) | 6.3 (4.1) | 72.8 (49.5) |
| (7.0 to 144) | (8.2 to 99) | (9.1 to 39.0) | (0.12 to 36.9) | (2.2 to 155) | |
| tPYD (nmol/mmol Cr) | 79.8 (45.7) | 41.1 (19.4) | 35.1 (12.9) | 22.3 (12.4) | 189 (72) |
| (19.2 to 200) | (19.9 to 123) | (17.1 to 70) | (8.9 to 72) | (57 to 295) | |
| fDPD (nmol/mmol Cr) | 8.5 (5.7) | 5.5 (4.0) | 6.1 (2.9) | 5.9 (5.1) | 28.2 (10.0) |
| (0.46 to 24.6) | (2.1 to 24.0) | (1.2 to 12.2) | (0.57 to 24.0) | (11.4 to 58) | |
| pDPD (nmol/mmol Cr) | 12.9 (12.4) | 6.8 (8.3) | 6.2 (5.1) | 2.5 (2.1) | 35.1 (24.1) |
| (0.3 to 57.5) | (0.4 to 49) | (0.43 to 22.9) | (0.5 to 15.4) | (1.6 to 89) | |
| tDPD (nmol/mmol Cr) | 21.4 (17.0) | 12.0 (8.6) | 12.3 (6.3) | 8.2 (6.3) | 63.3 (26.4) |
| (3.3 to 63) | (3.4 to 52) | (3.9 to 29.7) | (1.2 to 31.3) | (16.7 to 125) | |
| fPYD/fDPD | 4.4 (1.9) | 3.6 (1.4) | 3.0 (1.4) | 4.3 (3.9) | 4.3 (0.8) |
| (1.2 to 9.7) | (0.81 to 7.1) | (0.76 to 6.7) | (0.72 to 21.7) | (2.4 to 5.9) | |
| pPYD/pDPD | 8.5 (17.2) | 7.9 (12.2) | 6.6 (9.8) | 4.1 (8.6) | 4.8 (11.9) |
| (0.8 to 91) | (1.7 to 64) | (0.84 to 55) | (0.6 to 52) | (0.2 to 51) | |
| tPYD/tDPD | 4.4 (1.9) | 3.9 (1.7) | 3.3 (1.4) | 3.3 (1.6) | 3.0 (0.4) |
| (1.2 to 10.0) | (1.6 to 9.9) | (0.98 to 7.7) | (1.5 to 20.3) | (2.4 to 3.8) | |