Vector | Advantage | Disadvantage |
---|---|---|
AAV, adeno-associated virus. | ||
Adenovirus | Highly efficient transduction | Short term expression of the transgene (weeks) |
Relatively simple production | Potent immune response possible | |
Transduces non-dividing cells | ||
Large gene packaging capacity | ||
AAV | Efficient transduction | Limited packaging capacity (max 4.6 kb) |
Transduces non-dividing cells | Difficult to produce | |
Long term expression (months/years) | ||
Modest immune response | ||
Non-viral | Simple to produce | Low transduction efficiency |
Low immune response | Relatively short term expression (days) | |
Inexpensive |