Research agenda based on expert opinion
| 1 | Clinical predictors of response to pharmacological and non-pharmacological interventions need to be determined |
| 2 | There is a need to establish a set of recommendations for uniform and full reporting of clinical trials in knee OA |
| 3 | Studies should include quality of life and function as well as pain, as outcome measures |
| 4 | New imagining techniques—that is, MRI and ultrasound require validation for the diagnosis and follow up of knee OA |
| 5 | Randomised controlled trials should more fully assess non-pharmacological interventions for knee OA |
| 6 | The most efficient and effective exercises need to be determined |
| 7 | What is the effect on tissue, efficacy, and safety of long term COX 2 inhibition |
| 8 | The clinical relevance of structural modification requires evaluation |
| 9 | The indications for joint replacement need to be determined |
| 10 | There is a need to examine the efficacy and cost utility of surgical techniques |