Results of the transmission disequilibrium test performed for HLA-DR alleles carried on all haplotypes*
| Patients (n=169) | Unaffected HLA-B27+ siblings (n=71) | |||||||
|---|---|---|---|---|---|---|---|---|
| HLA-DR allele† | Transmitted | Not transmitted | p/pcorr‡ | Transmitted | Not transmitted | p‡ | Unmatched χ2 | p/pcorr§ |
| *pcorr, p value corrected for the number of comparisons; †number of alleles DR9, DR10, and DR12 available for transmission disequilibrium test were too small to give valid results; ‡p values were obtained using binomial probability; §p values were obtained using χ2 test to compare the balance of transmission between patients and HLA-B27+ siblings. | ||||||||
| DR1 | 46 | 21 | 0.002/0.02 | 22 | 11 | 0.11 | 0.04 | 0.84 |
| DR2 | 24 | 48 | 0.005/0.05 | 21 | 18 | 0.64 | 4.42 | 0.036/0.32 |
| DR3 | 20 | 38 | 0.02/0.18 | 11 | 18 | 0.2 | 0.1 | 0.75 |
| DR4 | 52 | 20 | 0.0002/0.002 | 10 | 18 | 0.13 | 11.4 | 0.0007/0.006 |
| DR7 | 26 | 32 | 0.43 | 8 | 14 | 0.2 | 0.47 | 0.49 |
| DR8 | 13 | 17 | 0.47 | 3 | 7 | 0.21 | 0.56 | 0.46 |
| DR11 | 44 | 36 | 0.38 | 25 | 16 | 0.16 | 0.4 | 0.53 |
| DR13 | 22 | 40 | 0.03/0.3 | 7 | 4 | 0.49 | 3.09 | 0.08 |
| DR14 | 22 | 13 | 0.13 | 10 | 6 | 0.37 | 0.0006 | 0.98 |