Effect of histamine H1 and H2 receptor antagonists, and indometacin, on the histamine stimulation of MMP-3 and MMP-13 production by HAC
| MMP-3 (ng/106cells/24 h) | MMP-13 (pg/106cells/24 h) | |
|---|---|---|
| Experiment 1. (HAC 2) | ||
| Control | 444.3 (47.8) | 343.9 (6.5) |
| + histamine (20 μM) | 694.2 (62.1) | 1049.0 (31.2) |
| + histamine + mepyramine (20 μM) | 223.8 (29.5) | 529.2 (15.8) |
| + histamine + ranitidine (20 μM) | 430.7 (41.6) | 829.1 (24.7) |
| Experiment 2. (HAC 5) | ||
| Control | 572.3 (34.8) | 190.9 (11.7) |
| + histamine (20 μM) | 962.4 (56.9) | 420.4 (37.8) |
| + indometacin (14 μM) | 609.0 (56.4) | 200.8 (19.7) |
| + histamine + indometacin | 670.1 (45.2) | 401.9 (41.7) |