High dose pravastatin may suppress amyloidogenesis
| Group III* experiment number | Type of experiment | Amyloid positive mice per group | Median (range) of amyloid grade | p Values† |
|---|---|---|---|---|
| *Amyloidosis was induced by amyloid enhancing factor and AgNO3. Study animals received intraperitoneally pravastatin 10 mg/day on days 0, 1, and 2. Control mice received 0.5 ml saline instead. The mice were killed after 72 hours (24 hours after the last pravastatin injection) and the amount of splenic amyloid was estimated by the Crush and Smear technique; †using Fisher's exact probability test. | ||||
| 1 | Study | 5/6 | 2.5 (0–3) | 0.24 |
| Control | 6/6 | 1.5 (1–3) | ||
| 2 | Study | 4/6 | 0.75 (0–1.5) | 0.03 |
| Control | 6/6 | 2.0 (0.5–3) | ||
| 3 | Study | 2/5 | 0.5 (0–3) | 0.07 |
| Control | 5/6 | 2.0 (0–2.5) | ||
| Combined | Study | 11/17 | 1.0 (0–3) | 0.05 |
| Control | 17/18 | 2.0 (0–3) | ||