Active RA | Inactive RA | Overall RA | Controls | |
---|---|---|---|---|
PBMCs, peripheral blood mononuclear cells; there was no correlation between age, duration of disease, rheumatoid factor positivity, or any second line drug with plasma or PBMC levels of Zn and Cu. | ||||
*Overall levels were significantly lower among patients than controls (p<0.05) and patients with active RA had lower levels than those with inactive RA (p<0.05); †overall levels were significantly higher among patients than controls (p<0.05) and patients with active RA as compared with those with inactive RA (p<0.05). There was overall a negative correlation between plasma and PBMC zinc levels (p<0.05); ‡overall, patients with RA had higher levels than controls (p<0.01) and those with active RA had higher levels than those with inactive disease (p<0.01); §overall, patients with RA had lower levels than controls (p<0.01) and those with active RA had lower levels than those with inactive disease (p<0.01). There was a negative correlation between plasma and PBMC copper levels (p<0.05). | ||||
Plasma zinc (μg/l)* | 687 (467) | 982 (264) | 824 (386) | 1024 (428) |
PBMC zinc (μg/106 cells)† | 135.2 (28.6) | 108.3 (38.4) | 121.4 (34.4) | 98.4 (16.4) |
Plasma copper (μg/l)‡ | 1646 (357) | 1016 (296) | 1426 (324) | 946 (446) |
PBMC copper (μg/106 cells)§ | 58.0 (43.2) | 86.4 (33.2) | 74.3 (38.2) | 104.2 (8.5) |