Average invasiveness in relation to expression of MMPs, cathepsin-K, and TIMP-1 and TIMP-2
| Average invasiveness | |||
|---|---|---|---|
| Low expression median (mean [IQR], n) | High expression median (mean [IQR], n) | Mann-Whitney test (p value) | |
| MMP-1 | 1605 (2663 [418–3916], 14) | 3835 (4458 [1867–6679], 42) | 0.03 |
| MMP-2 | 0 (0 [0–0], 0) | 3504 (4009 [1578–6486], 56) | – |
| MMP-3 | 1970 (2730 [740–4581], 26) | 4248 (5118 [2239–7943], 30) | 0.004 |
| MMP-7 | 3504 (4001 [1545–6408], 54) | 4247 (4247 [1843–6650], 2) | 0.844 |
| MMP-8 | 3523 (3995 [1668–6448], 53) | 1413 (4259 [1365–10000], 3) | 0.810 |
| MMP-9 | 3375 (3578 [1245–5203], 41) | 5050 (5190 [2695–7500], 15) | 0.066 |
| MMP-10 | 2360 (3411 [1125–5400], 39) | 4990 (5383 [3280–8070], 17) | 0.012 |
| MMP-11 | 3504 (3996 [1545–6409], 54) | 4358 (4358 [1915–6800], 2) | 0.717 |
| MMP-12 | 3504 (3903 [1535–6141], 52) | 4855 (5388 [2179–9131], 4) | 0.396 |
| MMP-13 | 3599 (3942 [1377–6486], 44) | 3133 (4254 [1996–6250], 12) | 0.576 |
| MMP-14 | 3774 (4026 [1660–6650], 27) | 3185 (3994 [1540–6448], 29) | 0.812 |
| MMP-17 | 3133 (3731 [1516–5413], 34) | 3708 (4439 [1639–6975], 22) | 0.45 |
| MMP-19 | 3599 (3663 [1265–5104], 34) | 3335 (4545 [1801–7028], 22) | 0.322 |
| Cathepsin-K | 1915 (3295 [205–7765], 3) | 3523 (4050 [1605–6448], 53) | 0.654 |
| TIMP-1 | 2010 (3273 [1007–6005], 12) | 3675 (4192 [1728–6650], 43) | 0.271 |
| TIMP-2 | 2498 (2464 [1439–3766], 8) | 3599 (4267 [1581–6736], 48) | 0.198 |