Mutual antagonism of atopy and inflammatory conditions
| Prevalence of atopic disorders | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Questionnaire (% positive) | Allergy test (% positive) | ||||||||
| Inflammatory condition | Dominant Th response | Controls/ inflam. (n) | Control | Inflam. | Difference (%) | Control | Inflam. | Difference (%) | Ref |
| Impact of inflammatory conditions on atopy | |||||||||
| RA | Th1 | 40/40 | 35 | 35 | 0 | 22.5 | 12.5 | −45* | 10 |
| RA | Th1 | 339/304 | 30 | 20 | −33 | 8 | 4 | −50†‡ | 12 |
| RA | Th1 | 173/173 | 18.8 | 7.5 | −60 | 9 | |||
| RA | Th1 | 248/102 | 21.9 | 14.7 | −33 | 11 | |||
| RA | Th1 | 536/487 | 20.7 | 13.1 | −37 | 13 | |||
| AS | Th? | 536/248 | 20.7 | 24.6 | +19 | 13 | |||
| Type 1 diabetes | Th1 | ?/157 | 51 | 27 | −48 | 14 | |||
| MS | Th1 | 18/24 | 50 | 21 | −58† | 15 | |||
| Tuberculin reactivity | Th1 | 290/213 | 46.8 | 25.8 | −45 | 55.8 | 41.8 | −25† | 16 |
| Inflammatory condition | Dominant Th response | Inhibited/stimulated disease characteristics (%) | Ref | ||||||
|---|---|---|---|---|---|---|---|---|---|
| RA, rheumatoid arthritis; AS, ankylosing spondylitis; MS, multiple sclerosis; DTH, delayed-type hypersensitiviy reaction. +, increased; −, decreased. Positive skin prick test to common allergens* and/or presence of specific IgE antibodies† are indicated. In one case only data for confirmed hay fever are shown‡. | |||||||||
| Impact of atopy on inflammatory conditions | |||||||||
| RA | Th1 | Acute phase responses | − | 12 | |||||
| Joint inflammation | − | ||||||||
| Joint destruction | − | ||||||||
| Th1 cytokine production | − | ||||||||
| RA | Th1 | Disease severity score | − | 13 | |||||
| AS | Th? | Disease severity score | + | 13 | |||||
| Tuberculin. reactivity | Th1 | DTH responses | − | 16 | |||||
| Th1 cytokine production | − | ||||||||