Table 2

Shared epitope frequencies in patients with young onset RA (YORA), elderly onset RA (EORA), and in controls

YORA (n=262)EORA (n=60)Controls (n=1609)
No %
No (%)OR2-150 (95% CI)No (%)OR2-150 (95% CI)
SE2-150 homozygotes 17  (6)13.9  (5.9  to  32.5)2  (3)2-151 6.9  (1.4  to  33.2)8  (0.5)
SE heterozygotes39 (15)4.4 (2.9 to  6.8)5 (8)2-151 2.3 (0.9 to  5.9)61 (3.8)
SE/DRx139 (53)2.0 (1.5 to  2.6)36 (60)2-151 2.7 (1.5 to  4.5)576 (35.8)
DRx/DRx2-152 67 (26)0.2 (0.1 to  0.3)17 (28)2-151 0.3 (0.1 to  0.5)964 (59.9)
  • 2-150 OR (95% CI) = odds ratio (95% confidence interval) versus controls; SE = shared epitope.

  • 2-151 EORA versus YORA: NS.

  • 2-152 DRx = any DR gene but RA associated alleles.