Individual circadian rhythm characteristics for pain rating, stiffness rating, and dexterity
| Variable: | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pain rating | Best fitting | Stiffness rating | Best fitting | Dexterity | Best fitting | |||||||||||||||||
| Fitted period = 24.0 h | Circadian period | Fitted period=24.0 h | Circadian period | Fitted period=24.0 h | Circadian period | |||||||||||||||||
| Patient/ sex | N | p Value | M | A | (%A) | bØ (h) | Hours | p Value | p Value | M | A | (%A) | bØ (h) | Hours | p Value | p Value | M | A | (%A) | bØ (h) | Hours | p Value |
| Data obtained by self measurement every 2–4 h during waking only for 10 days. Any series with a significant trend had the trend removed before analysis for circadian rhythm by the least squares fit of a 24.0 h cosine. Each series was also analysed for best fitting cosine in the circadian domain between 14 and 34 h. | ||||||||||||||||||||||
| For rhythm characteristics: p value from zero amplitude test; M=mesor (middle value of fitted cosine); A=amplitude (distance from M to peak or trough of cosine); %A=% amplitude (A as % of M); bØ=bathyphase (lowest point of fitted cosine, referenced from 00:00h). | ||||||||||||||||||||||
| 1F | 60 | 0.150 | 14.2 | 5.1 | (36) | 15:42 | 23.9 | 0.147 | <0.001 | 18.9 | 14.0 | (74) | 15:44 | 24.1 | <0.001 | <0.001 | 70.2 | 6.5 | (9) | 15:36 | 23.7 | <0.001 |
| 3F | 49 | <0.001 | 67.7 | 7.8 | (12) | 07:08 | 23.8 | <0.001 | <0.001 | 48.0 | 18.2 | (38) | 16:14 | 24.2 | <0.001 | <0.001 | 55.4 | 6.4 | (12) | 16:37 | 23.8 | <0.001 |
| 4F | 60 | 0.020 | 2.2 | 1.3 | (60) | 17:18 | 24.3 | 0.012 | 0.015 | 12.6 | 4.2 | (34) | 17:59 | 24.6 | 0.001 | <0.001 | 67.3 | 8.2 | (12) | 15:55 | 24.0 | <0.001 |
| 5F | 52 | 0.786 | 2.3 | 0.1 | (5) | 05:12 | 22.3 | 0.049 | 0.041 | 5.0 | 1.1 | (21) | 15:50 | 24.5 | 0.012 | 0.022 | 64.3 | 4.2 | (7) | 15:02 | 24.7 | <0.001 |
| 6F | 44 | 0.035 | 21.2 | 7.7 | (36) | 13:10 | 24.1 | 0.035 | 0.005 | 38.7 | 17.6 | (45) | 15:42 | 23.4 | <0.001 | 0.259 | 113.8 | 13.0 | (11) | 14:49 | 23.7 | 0.224 |
| 7F | 60 | 0.214 | 3.5 | 0.9 | (27) | 12:44 | 23.2 | 0.057 | 0.327 | 71.3 | 1.0 | (1) | 17:52 | 20.9 | 0.112 | 0.323 | 70.8 | 2.7 | (4) | 17:03 | 21.6 | 0.045 |
| 8F | 59 | 0.191 | 6.0 | 0.4 | (7) | 12:02 | 23.0 | 0.124 | 0.721 | 8.0 | 0.2 | (3) | 10:38 | 26.8 | 0.330 | <0.001 | 47.1 | 1.7 | (4) | 09:30 | 23.5 | <0.001 |
| 9F | 46 | 0.007 | 61.7 | 6.2 | (10) | 17:02 | 23.8 | 0.005 | 0.126 | 79.6 | 4.4 | (6) | 14:46 | 24.7 | 0.017 | <0.001 | 64.3 | 7.7 | (12) | 16:05 | 24.0 | <0.001 |
| 10F | 60 | 0.138 | 9.1 | 2.7 | (30) | 16:51 | 23.6 | 0.100 | 0.042 | 17.9 | 5.2 | (29) | 14:48 | 22.8 | 0.003 | <0.001 | 95.2 | 10.4 | (11) | 15:04 | 23.8 | <0.001 |
| 11F | 60 | <0.001 | 48.8 | 15.8 | (32) | 20:32 | 24.2 | <0.001 | <0.001 | 40.0 | 10.7 | (27) | 18:48 | 24.2 | <0.001 | <0.001 | 75.3 | 10.2 | (14) | 17:15 | 24.3 | <0.001 |
| 15F | 48 | <0.001 | 40.6 | 13.6 | (34) | 18:34 | 23.9 | <0.001 | 0.011 | 50.0 | 13.2 | (26) | 18:26 | 25.2 | <0.001 | <0.001 | 57.9 | 7.3 | (13) | 17:22 | 24.1 | <0.001 |
| 16F | 58 | 0.367 | 36.1 | 1.9 | (5) | 01:53 | 21.8 | 0.013 | – | – | – | – | – | – | – | 0.102 | 77.7 | 1.8 | (2) | 14:02 | 22.4 | 0.011 |
| 17F | 56 | 0.303 | 13.7 | 2.2 | (16) | 22:44 | 24.6 | 0.252 | 0.219 | 12.3 | 2.4 | (19) | 23:33 | 24.8 | 0.110 | 0.088 | 71.9 | 2.3 | (3) | 09:38 | 23.6 | 0.069 |
| 18F | 43 | 0.050 | 52.0 | 8.1 | (15) | 13:30 | 23.6 | 0.023 | <0.001 | 43.0 | 13.5 | (31) | 13:33 | 24.1 | <0.001 | 0.002 | 102.0 | 17.8 | (17) | 14:54 | 24.1 | 0.002 |
| 19F | 50 | 0.200 | 11.0 | 2.7 | (24) | 10:15 | 23.2 | 0.128 | 0.006 | 17.5 | 5.7 | (32) | 14:19 | 23.7 | 0.002 | 0.095 | 81.6 | 7.0 | (9) | 15:02 | 23.2 | 0.005 |
| 20F | 52 | 0.002 | 71.1 | 7.8 | (11) | 10:14 | 24.5 | <0.001 | 0.005 | 72.7 | 6.3 | (9) | 11:56 | 24.6 | <0.001 | 0.042 | 103.6 | 5.9 | (6) | 11:22 | 23.3 | 0.030 |
| 21F | 60 | <0.001 | 66.2 | 16.6 | (25) | 18:01 | 23.8 | <0.001 | <0.001 | 60.3 | 14.1 | (23) | 17:39 | 23.7 | <0.001 | <0.001 | 76.4 | 11.6 | (15) | 17:46 | 24.0 | <0.001 |
| 2M | 60 | 0.022 | 45.8 | 4.0 | (9) | 20:42 | 23.4 | 0.014 | 0.215 | 52.1 | 4.4 | (8) | 16:24 | 23.8 | 0.200 | 0.159 | 82.7 | 4.7 | (6) | 15:16 | 23.1 | 0.050 |
| 12M | 60 | 0.020 | 49.2 | 3.1 | (6) | 18:10 | 23.7 | 0.017 | <0.001 | 59.8 | 10.0 | (17) | 16:27 | 23.9 | <0.001 | <0.001 | 73.4 | 8.1 | (11) | 16:18 | 23.8 | <0.001 |
| 13M | 60 | 0.088 | 27.2 | 4.4 | (16) | 14:46 | 24.8 | 0.002 | 0.034 | 30.0 | 5.2 | (17) | 14:43 | 24.8 | <0.001 | 0.162 | 67.7 | 2.6 | (4) | 14:39 | 26.9 | 0.059 |
| 22M | 55 | 0.790 | 5.6 | 0.7 | (12) | 07:32 | 32.3 | 0.023 | 0.049 | 13.8 | 4.3 | (31) | 19:27 | 23.5 | 0.022 | <0.001 | 76.4 | 7.1 | (9) | 17:28 | 23.8 | <0.001 |