Table 1

Expression of activation markers and costimulatory molecules on peripheral blood lymphocytes. Results are given as mean (SD)

Control Inactive Active
CD4/CD25+ (%)4.0 (1.4)4.4 (3.2)8.5 (6.3)1-150
CD8/HLA-DR+ (%)5.6 (2.5)8.1 (5.3)10.6 (8.3)
CD19/CD38+ (%)79.7 (8.7)84.3 (7.7)86.5 (9.8)1-150
CD4/CD28+ (%)95.3 (3.8)93.6 (7.9)95.0 (3.5)
CD19/CD40+ (%)85.0 (9.3)81.3 (11.2)81.9 (12.4)
CD19/CD80+ (%)1.7 (0.9)3.1 (5.7)4.4 (5.8)
CD19/CD86+ (%)2.9 (1.4)6.9 (7.2)1-150 12.5 (8.9)1-165

  • ↵1-150 p<0.05,

  • ↵1-165 p<0.001 compared with controls. Percentages are expressed as proportion of total CD4+, CD8+, and CD19+ subpopulations from healthy controls (n=10), patients with inactive disease (n=20), and patients with active disease (n=13).