Table 1

Patient characteristics at the time of inclusion (blank spaces indicate negative findings)

Patient number	Age	SLE duration	Anti-DNA antibodies	aPL^*	White matter lesions^*	Cerebral infarction	Cortical atrophy^*	Disease severity	Currently active CNS manifestation^*	SLEDAI	Prednisolone (mg/day)
1	50	4	1/100	+				3	Dementia, seizures,	26	0
2	47	13		+		Yes		1	Fatigue, depression	8	5
3	23	1		+				1	Fatigue, Cogn	0	0
4	49	10		+	ND			1	Vertigo, fatigue	4	15
5	61	12			++			3	Psychosis, seizures	20	40
6	45	14		+				2	Cogn, Ha	8	5
7	39	13					++	2	Cogn, seizures	16	5
8	57	21	1/100	+	++	Yes	+	3	OBS, seizures	16	7.5
9	51	2	1/400	+				3	Psychosis, Cogn	16	20
10	49	1	1/3200	+	+		+	1	Ha, anxiety	25	40
11	47	1		+				1	Ha, Cogn	8	0
12	22	6	1/25	+				2	OBS	20	0
13	37	22	1/3200	+				1	Ha, fatigue	6	10
14	56	12		+	++			2	Seizures, Cogn	20	0
15	58	27	1/1600	+			++	2	Seizures	13	20
16	74	2		+	++		++	2	Seizures, Ha	17	20
17	26	1	1/100	+				1	Cogn, Ha	14	15
18	42	27	1/100	+	++			3	OBS, PN, Ha	18	0
19	50	2	1/10		++			2	Cogn, fatigue	8	0
20	55	2						2	Seizures	12	0
21	20	1						1	Cogn, Ha	1	5
22	52	19	1/25	+	+	Yes		2	Ha	13	5
23	63	2		+	+	Yes	++	2	OBS, Ha	8	3.75
24	67	54		+	ND		+	2	OBS, Ha	9	0
25	50	22		+				1	Cogn	8	5
26	34	4		−				1	Ha	12	7.5
27	52	24		+	++	Yes	+	3	OBS, seizures	26	17.5
28	38	3		+	+			1	Cogn, Ha	10	0
29	25	2		−				1	Fatigue, Ha	14	0
30	38	21		+	+	Yes		3	Myelopathy, Ha	8	30

aPL = antiphospholipid antibodies: + = present as either IgG cardiolipin antibodies, IgM cardiolipin antibodies or positive lupus anticoagulant test; white matter lesions (WML) on MRI: + = moderate changes 4–10 WML, ++ = severe changes 11–30 WML, ND = MRI not done, only computed tomography performed; cortical atrophy with cerebral sulci wider than 5 mm: + = moderate changes, ++ = severe changes; seizures were considered currently active if previously documented and had occurred within 10 days before inclusion: Cogn = subjective complaint of cognitive dysfunction, OBS = organic brain syndrome; Ha = severe headache; PN = peripheral neuropathy.