Laboratory parameter | Patient 1 | Patient 2 | Patient 3 | Normal values |
Thrombocyte count (× 109/l) | 214 | 179 | 336 | 150–350 |
Anticardiolipin antibodies | ||||
IgM | +++ | − | − | −ve |
IgG | +++ | ++ | +++ | −ve |
Lupus anticoagulant | −ve | −ve | −ve | −ve |
Wassermann test | −ve | −ve | −ve | −ve |
aPTT (seconds) | 38 | 35 | 29 | 20–40 |
Fibrinogen (g/l) | 6.0 | 5.8 | 3.8 | 2.0–4.0 |
Creatinine (μmol/l) | 134 | 85 | 177 | 55–110 |
Triglycerides (mmol/l) | 3.2 | 2.1 | 1.5 | 0.5–2.0 |
Cholesterol (mmol/l) | 4.2 | 6.8 | 3.9 | 4.0–6.5 |
HDL cholesterol (mmol/l) | 0.7 | 1.0 | 1.0 | >1.0 |
LDL cholesterol (mmol/l) | 2.1 | 3.7 | 2.3 | 1.68–4.53 |
Vitamins (before treatment) | ||||
Vitamin B6 (nmol/l) | 95 | ND | ND | 35–105 |
Vitamin B12 (nmol/l) | 0.18 | 0.19 | 0.46 | 0.13–0.60 |
Folate (nmol/l) | 4.1 | 4.1 | 9.9 | 5.0–30.0 |
Methionine loading (I) (μmol/l) | ||||
Homocysteine (pre/post) | 103/159 | 42/78 | 27/94 | <15/<50 |
Methionine loading (II) (after folate treatment) | ||||
Homocysteine (pre/post) | 13/52 | 8.6/28.6 | 18/52 |
aPTT = activated partial thrombin time; HDL = high density lipoprotein; LDL = low density lipoprotein; ND = not determined.