Table 1

Lymphoma characteristics, conditioning regimens, side effects and outcome of the two female patients so far studied, after haematopoietic stem cell transplantation

Variables Patient 1 Patient 2
Age (years)5734
DiagnosisNHL1-150 of the lung (large cells MALT1-150lymphoma)Immunoblastic B lymphoma
First line treatment6 cycles of F-MACHOP1-150 VACOP-B1-150 followed by VIPE1-150
Conditioning regimensARA-C1-150 200 mg × 2/day × 4BCNU 300 mg/m2
VP161-150 200 mg × 2/day × 4Etoposide 800 mg/m2
CTX1-150 1500 mg/day × 4Cytarabine 1600 mg/m2
BCNU1-150 200 mgMelphalan 140 mg/m2
ReinfusionMNC1-150 4.5 × 108/kgMNC 2.42 × 108/kg
CD34 0.9 × 106/kgCD34 4.60 × 106/kg
CD3 not countedCD3 37.03 × 106/kg
Days to PMN1-150 >1 × 109/l = 10 daysDays to PMN >10 × 109/l = 11 days
Days to Plt1-150 >20 × 103/l = 8 daysDays to Plt >50 × 103/l = 18 days
Sides effects/outcomesAlive in complete continous lymphoma remission after 3 yearsNo remission of autoimmune disease
No remission of autoimmune diseaseDied 20 months after transplantation for Pneumocystis carinii pneumonia
  • 1-150 NHL = non-Hodgkin's lymphoma; MALT = mucosa associated lymphoid tissue; F-MACHOP: F = 5-fluorouracil, M = methotrexate, A = Adriamycin, C= cyclophosphamide, H = doxorubicin, O = Oncovin, P = prednisone; ARA-C = arabinoside-C; VP16 = etoposide; CTX = cyclophosphamide; BCNU = carmustine; MNC = mononuclear cells; PMN = polymorphonuclear cells; Plt = platelets; VACOP-B: V = Vepesid, A = Adriamycin, C = cyclophosphamide, O = vincristine, P = prednisone, B = bleomycin; VIPE: V = vinblastine, I = ifosfamide, P = prednisone, E = etoposide.