Main clinical, laboratory, and other diagnostic parameters investigated
| Skin: | Lung: |
| Total skin score | Dyspnoea |
| Scleredema | Pleural rubs/pericarditis |
| Melanoderma | Bibasilar crackles |
| Telangiectasia | FVC2-150 |
| Calcinosis (clinically evident) | Tlco2-150 |
| Digital pitting scars | Chestx ray |
| Digital infarcts | Chest HRCT2-150 |
| Pulmonary arterial pressure (echocardiodoppler) | |
| Joints/tendons/muscles: | Heart: |
| Arthralgias/arthritis | Pericarditis |
| Flexion contractures | Cardiac failure |
| Tendon friction rubs | Conduction defects (ECG) |
| Muscle weakness | Arrhythmias (ECG, Holter ECG) |
| Serum CK2-150 | |
| Gut: | Kidney: |
| Pyrosis/dysphagia | Urine analysis (proteinuria, haematuria) |
| Diarrhoea | Creatinine |
| Oesophageal hypomotility | Systemic arterial pressure |
| Small bowel hypomotility |
↵2-150 CK = creatine kinase; FVC = forced vital capacity; Tlco = carbon monoxide transfer factor; HRCT = high resolution computed tomography.