Table 2

Anti-onconeural antibodies and their clinical significance

Autoantibody Cancer association Clinical significance Reference
Anti-HuSmall cell lung cancerEncephalomyelitis 37-39, 75
Acute sensory or autonomic neuropathy
Neuromyotonia
Anti-VGCCSmall cell lung cancerLambert-Eaton myasthenic syndrome 76, 77
Anti-amphiphysinSmall cell lung cancerStiff man syndrome 79
Breast cancer
Thymoma
Anti-YoBreast cancerCerebellar degeneration 40, 41
Ovarian cancer
Small cell lung cancer
Anti-RiBreast cancerMyoclonous 40, 42
Ovarian cancerCerebellar degeneration
Small cell lung cancer
Anti-TrHodgkin's diseaseCerebellar degeneration 43, 44