Autoantigen
|
Characteristics of autoantigen
|
Autoantibody
|
References
|
Oncoproteins | Proteins encoded by oncogenes which play a part in the control of cell growth | Anti-HER-2/neu |
6, 17 |
Tumour suppressor gene proteins | Proteins encoded by tumour suppressor genes, expressed in normal tissues | Anti-P53 |
19-26
|
Proliferation associated antigens | Nuclear and cytoplasmic antigens associated with cell cycle regulation and mitosis | Anti-cyclin B1, anti-cyclin A, anti-CENP-F |
28-32 |
Onconeural antigens | Antigens normally found in the nervous system, may be expressed by malignant cells | Anti-Hu, Anti-Yo |
37, 39
|
Cancer/testis antigens | Normally found in testis and expressed in various malignancies | Anti-NY-ESO-1, anti-MAGE-1 |
45, 46
|
Autoimmune rheumatic diseases | Normal nuclear and cytoplasmic antigens | ANA, anti-NDA, anti-Sm |
47
|