Table 1

Autoantigens that may induce autoantibody secretion among patients with malignancies

Autoantigen Characteristics of autoantigen Autoantibody References
OncoproteinsProteins encoded by oncogenes which play a part in the control of cell growthAnti-HER-2/neu 6, 17
Tumour suppressor gene proteinsProteins encoded by tumour suppressor genes, expressed in normal tissuesAnti-P53 19-26
Proliferation associated antigensNuclear and cytoplasmic antigens associated with cell cycle regulation and mitosisAnti-cyclin B1, anti-cyclin A, anti-CENP-F 28-32
Onconeural antigensAntigens normally found in the nervous system, may be expressed by malignant cellsAnti-Hu, Anti-Yo 37, 39
Cancer/testis antigensNormally found in testis and expressed in various malignanciesAnti-NY-ESO-1, anti-MAGE-1 45, 46
Autoimmune rheumatic diseasesNormal nuclear and cytoplasmic antigensANA, anti-NDA, anti-Sm 47