Toxicity leading to withdrawal
| Gold No (%) | Methotrexate No (%) | |
| Gastrointestinal disturbance | 2 (3) | 5 (7) |
| Proteinuria | 12 (17) | 1 (1) |
| Pruritis | 1 (1) | |
| Skin rash | 6 (8) | |
| Mouth ulcers/stomatitis | 3 (4) | 1 (1) |
| Vasovagal | 1 (1) | — |
| Leucopenia <4×109/l | 4 (6) | — |
| Thrombocytopenia <150×109/l | 2 (3) | — |
| Raised AST/ALT5-150>2×normal | — | 3 (4) |
| Infection | — | 3 (4) |
↵5-150 AST/ALT = serum aspartate transaminase/serum alanine transaminase.