Univariate analysis of potential risk ractors for infection in a single cohort of 87 adults with systemic lupus erythematosus (SLE)
| Factor |
Infected (n=57) | Non-infected (n=52) | p Value |
| During SLE | |||
| Total number of SLE flares | 2.6 (1.5) | 1.8 (1.1) | <0.02 |
| Duration (years) | 11.8 (6.6) | 8.4 (8.5) | <0.05 |
| SLE glomerulonephritis | 23/57 (40%) | 10/52 (19%) | <0.05 |
| Treatments | |||
| Oral corticosteroids | 50/57 (88%) | 38 (73%) | NS |
| Oral corticosteroids (cumulative dose in g) | 30.9 (40.3) | 8.5 (15.4) | <0.005 |
| Intravenous corticosteroids | 27/57 (47%) | 6 (11%) | <0.0001 1-151 |
| Intravenous corticosteroids (cumulative dose in g) | 1.3 (2.2) | 0.4 (1.4) | 0.01 |
| Immunosuppressive treatment | 32/57 (56%) | 11 (21%) | <0.0005 1-151 |
| Pulse cyclophosphamide | 26/57 (46%) | 9 (17%) | <0.003 |
| Pulse cyclophosphamide (cumulative dose in mg) | 5004 (5603) | 1067 (3397) | <0.01 |
| Plasmapheresis | 17/57 (30%) | 4 (8%) | <0.01 |
The infected group consisted of 35 adults with a total of 57 infectious episodes. Where applicable, values are mean (SD).
↵1-151 Retained as an independent risk factor for infection after multivariate analysis (intravenous corticosteroids: p<0.001; immunosuppressive treatment: p<0.01).
NS = Not significant.