Table 2

Proportions of PIP joints showing significant erosion of cartilage and/or bone in mice treated with anti-CD4 alone, anti-TNF alone or anti-CD4 plus anti-TNF

TreatmentJoints with erosions
Suboptimal anti-TNF (50 μg)
anti-CD4 alone13/18 (72%)
anti-TNF alone14/19 (74%)
anti-CD4/anti-TNF4/18 (22%)2-150
control mAb17/18 (94%)
Optimal anti-TNF (300 μg)
anti-CD4 alone10/12 (83%)
anti-TNF alone6/11 (54%)2-151
anti-CD4/anti-TNF4/13 (31%)2-152
control mAb12/12 (100%)

  • ↵2-150 p<0.01 (anti-CD4/TNF v control mAb),

  • ↵2-151 p<0.01 (anti-TNF alone v control mAb),

  • ↵2-152 p<0.01 (anti-CD4/TNF v control mAb). Modified from Williams et al.54