Table 2

Surrogate parameters for vasculitis

Organ involvement Surrogate parameters
GlomerulonephritisProteinuria and haematuria with red blood cell casts
ArteritisAngiographic or ultrasonic demonstration of aneurysms or stenoses in arteries provided the patient demonstrated other signs of vasculitis
Granulomatous inflammation in lower airwaysRadiologically demonstrated pulmonary infiltrates or cavitations of more than one month's duration provided that all other causes such as infections and malignancies were ruled out
Granulomatous inflammation in upper airwaysBloody nasal discharge and/or crusting of more than one month's duration; chronic sinusitis, otitis and/or mastoiditis (proved by radiograph, CT or MRI); cranial bone and/or cartilage destruction; acute hearing loss, without signs of traumatic disease