Strategy I | Strategy II | Strategy III | |
Gastrointestinal (subjective) | |||
Nausea, vomiting, dyspepsia, epigastric pain, indigestion | 35 | 21 | 39 |
Diarrhoea | 17 | 7 | 5 |
Dysgeusia | — | 4 | 1 |
Gastrointestinal (objective) | |||
Gastric ulcer | 1 | 1 | 1 |
Gastritis | — | — | 2 |
Gastrointestinal bleeding | — | — | 1 |
Colitis | 1 | — | 1 |
Colorectal surgery | 1 | — | — |
Mucocutaneous | |||
Rash | 17 | 47 | 10 |
Stomatitis, mouth ulcers | 2 | 12 | 4 |
Alopecia | 1 | 3 | 7 |
Photosensitivity | 1 | — | — |
Central nervous system | |||
Headache, dizziness, tinnitus, mood alterations | 9 | 7 | 9 |
Concentration disturbances | 5 | — | 1 |
Renal | |||
Proteinuria (>0.1 g/l in 24 h) | 2 | 11 | 2 |
Raised serum creatinine (>120 μmol/l) | 7 | 8 | 9 |
Oedema (pretibial) | 2 | 3 | 3 |
Haematuria (macroscopic observation) | — | 1 | 2 |
Foul odour urine | — | 1 | 1 |
Hepatotoxicity | |||
Raised transaminases or γGT6-150 (ALAT6-150>90 U/l, γGT>100 U/l) | 7 | 9 | 23 |
Haematological | |||
Anaemia (Hb <6.5 mmol/l) | 21 | 12 | 9 |
Leucopenia (<3.5 × 109/l) | — | 9 | 3 |
Thrombocytopenia (<150 × 109/l) | 3 | 10 | 6 |
Eosinophilia (>0.5 × 109/l) | — | 2 | — |
Pancytopenia | — | 1 | — |
Leucopenia and thrombocytopenia | — | 2 | — |
Respiratory system | |||
Persistent cough | 1 | 3 | 3 |
Dyspnoea | 1 | 2 | 1 |
Pneumonitis | — | 1 | 1 |
Pulmonary disorder (other than pneumonitis) | 2 | 1 | 1 |
Disorders of eye or ear | |||
Disturbed vision (unspecified) | 4 | 2 | 5 |
Cataract | — | 1 | 3 |
Blepharitis | 2 | 1 | — |
Conjunctivitis | 1 | — | — |
Scleritis | — | 1 | — |
Toxic keratitis | — | — | 1 |
Ocular sarcoidosis | 1 | — | — |
Glaucoma | — | 1 | — |
Dry eyes/dry mouth | — | 1 | — |
Impaired hearing | — | 1 | — |
Other | |||
Fever, infections | 12 | 12 | 18 |
Rheumatoid nodulosis | 4 | 3 | 2 |
Weight loss | 4 | 3 | — |
Fatigue | 3 | — | 2 |
Neuropathy | 1 | 2 | 1 |
Vertebral fracture, osteoporosis | 1 | 1 | 2 |
Malignancy | — | 2 | 2 |
Heart failure | — | 2 | — |
Sexual impotence | — | 1 | — |
Restless legs | 1 | — | — |
Total | 170 | 212 | 181 |
↵6-150 γGT = γ-glutamyl transferase; ALAT = alanine aminotransferase.