Three month treatment effect of doxycycline compared with placebo for chronic seronegative or reactive arthritis
| Doxycycline (n=16) | Placebo (n=21) | Comparison | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 m | 3 m | Change | 0 m | 3 m | Change | Mean difference (95% CI) | p3-150 | ||||
| AIMS23-151pain | 10.8 | 13.5 | 2.7 | 12.7 | 13.8 | 1.1 | 1.5 (−1.2 to 4.2) | 0.25 | |||
| AIMS2 function3-152 (4 scales) | 71.9 | 75.1 | 3.2 | 73.0 | 75.4 | 2.4 | 0.8 (−5.6 to 7.1) | 0.81 | |||
| AIMS2 mobility | 21.5 | 22.1 | 0.6 | 21.1 | 21.7 | 0.6 | 0.0 (−3.2 to 3.1) | 0.97 | |||
| AIMS2 walking and bending | 13.2 | 16.3 | 3.2 | 15.1 | 16.6 | 1.6 | 1.6 (−0.9 to 4.2) | 0.21 | |||
| AIMS2 self care | 18.9 | 19.4 | 0.6 | 19.1 | 19.2 | 0.2 | 0.4 (−1.1 to 1.8) | 0.61 | |||
| AIMS2 household tasks | 18.4 | 17.3 | −1.1 | 17.9 | 17.9 | 0.0 | −1.2 (−3.0 to 0.6) | 0.19 | |||
| AIMS2 hand and finger | 11.1 | 10.5 | −0.6 | 8.8 | 8.2 | −0.6 | 0.0 (−2.3 to 2.2) | 0.97 | |||
| AIMS2 arm | 10.9 | 9.1 | −1.9 | 7.4 | 6.8 | −0.6 | −1.3 (−3.0 to 0.5) | 0.15 | |||
| AIMS2 mood | 18.5 | 19.2 | 0.7 | 19.0 | 20.0 | 1.0 | −0.3 (−2.0 to 1.4) | 0.72 | |||
| AIMS2 tension | 14.8 | 15.3 | 0.5 | 16.2 | 17.6 | 1.4 | −0.9 (−3.0 to 1.2) | 0.38 | |||
| AIMS2 family and friends | 6.8 | 7.4 | 0.6 | 7.2 | 8.5 | 1.3 | −0.7 (−2.6 to 1.1) | 0.41 | |||
| AIMS2 social activity | 15.6 | 15.5 | −0.1 | 16.5 | 16.5 | 0.0 | −0.1 (−2.7 to 2.6) | 0.96 | |||
| AIMS2 work | 12.2 | 12.2 | 0.0 | 14.9 | 17.4 | 2.5 | −2.5 (−5.4 to 0.5) | 0.10 | |||
| Joint count | 4.0 | 5.6 | 1.6 | 5.4 | 5.5 | 0.1 | 1.6 (−1.6 to 4.7) | 0.32 | |||
| Pain score (VAS3-153) | 4.3 | 4.6 | 0.3 | 3.6 | 4.5 | 0.9 | −0.6 (−3.1 to 1.9) | 0.46 | |||
| Functional score (VAS) | 4.0 | 3.7 | −0.3 | 2.2 | 2.8 | 0.7 | −0.9 (−2.5 to 0.7) | 0.15 | |||
| Arthritis activity (VAS) | 4.5 | 4.7 | 0.1 | 3.6 | 4.4 | 0.8 | −0.6 (−3.1, 1.9) | 0.48 | |||
↵3-150 Change score means compared by unpairedt test (SPSS).
↵3-151 AIMS2 = Arthritis Impact Measurement Scales version 2 self assessed questionnaire (n=37). Lower numbers indicate a worse score. AIMS2 pain and composite functional scores constituted the primary study end points.
↵3-152 Composite functional score consists of sum of mobility, walking and bending, self care, and household tasks AIMS2 scales.
↵3-153 VAS = visual analogue scale (0 = best, 10 = worst) assessed by rheumatologist (n=25).