Clinical characteristics of patients with systemic lupus erythematosus (SLE) complicated by avascular necrosis (AVN) of bone
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Patient No | Age | Sex | Ethnic origin | Smoker | Drinker |
Age at presentation of lupus |
Age at presentation of AVN | Interval between onset of SLE and AVN (years) | Site(s) of AVN | Surgical intervention | Other systemic manifestations | Other diseases /risk factors |
| 1 | 39 | F | W | −ve | −ve | 17 | 40 | 23 | L2 lumbar vertebral body | L1-3 fusion | Arth, DVT, Fever, TP, MisC, CNS | HT |
| 2 | 39 | F | W | −ve | Social | 19 | 23 | 4 | Both femoral heads | RTHR, LTHR | Arth, GN, rash, TP | HT |
| 3 | 36 | F | A/AC | −ve | −ve | 23 | 34 | 11 | Both femoral heads | None | Arth, CNS, CV, GN | HT |
| 4 | 33 | F | A | −ve | −ve | 20 | 26 | 6 | Both femoral heads | None | Arth, CV, LN, MU, Pan, Ple, Peric, Poor LVF, rash, Ray | Hypothy |
| 5 | 55 | F | W | −ve | −ve | 23 | 31 | 8 | Both femoral heads | None | Alp, discoid rash, AIHA, GN | HT |
| 6 | 36 | F | AC | −ve | −ve | 22 | 26 | 4 | Left femoral head, right prox tibia + right distal femur | LTHR | AIHA, Arth, CNS, CV, LN, discoid rash, Ple, Peric, Hep | Nil |
| 7 | 37 | F | W/A | −ve | −ve | 28 | 31 | 3 | Both femoral heads | RTHR, LTHR | Arth, GN, Ple | HT, obesity |
| 8 | 44 | F | W | +ve | −ve | 22 | 38 | 16 | Both femoral necks | None | Arth, CNS, Peric, Ple, rash, MisC, DVT | IHD, asthma |
| 9 | 46 | F | AC | −ve | −ve | 26 | 40 | 14 | Right femoral head | None | Arth, AIC, PN, rash, SS | Nil |
| 10 | 20 | F | A | −ve | −ve | 15 | 25 | 10 | Left femoral head | None | Alp, CV, GN, LN, lung, Ray | Nil |
| 11 | 27 | F | A | −ve | −ve | 19 | 21 | 2 | Both femoral necks | Decompression on R side | Alp, Arth, Fever, LN, Ple, Ray | Childhood rickets, Hypothy |
A = Asian; AC = Afro-Caribbean; AIC = autoimmune interstitial cystitis; AIHA = autoimmune haemolytic anaemia; Alp = alopecia; Arth = arthritis/arthralgia; CNS = cerebral lupus; CV = cutaneous vasculitis; DVT = deep vein thrombosis; GN = lupus glomerulonephritis; Hep = autoimmune hepatitis; Hypothy = autoimmune thyroid disease (hypothyroidism); HT = hypertension; IHD = ischaemic heart disease; LN = lymphadenopathy; LTHR = left total hip replacement; LVF = left ventricular function; MisC = miscarriages; MU = mouth ulcers; Pan = pancytopenia; Ple = pleuritis; Peric = pericarditis; PN = peripheral neuropathy; Ray = Raynaud's phenomenon; RTHR = right total hip replacement; SS = Sjögren's syndrome; TP = autoimmune thrombocytopenia; W = white.