Clinical results with a single infusion of infliximab in patients who had failed DMARDs
| Placebo | 1 mg/kg infliximab | 10 mg/kg infliximab | |
| Paulus 20 (% patients) | 8 | 44 | 79 |
| p=0.008 | p<0.0001 | ||
| Paulus 50 (% patients) | 8 | 28 | 58 |
| p=0.1 38 | p<0.0005 | ||
| % reduction in SJC | 2 | 40 | 61 |
| p<0.001 | p<0.001 | ||
| % reduction in TJC | 6 | 42 | 60 |
| p<0.001 | p<0.001 |
Adapted from Elliot et al.8
Patients had failed treatment with at least one DMARD and did not receive methotrexate during the trial. Patients were withdrawn from their DMARD treatments at least four weeks before entry into the study. The study population totalled 72 patients. Data shown are results at four weeks after a single infusion.