Density and affinity of [125I]351A binding to human synovium
| Stroma | Blood vessels | ||||||
|---|---|---|---|---|---|---|---|
| CMP (n=6) | OA (n=7) | RA (n=6–7) | CMP (n=6) | OA (n=7) | RA (n=6–7) | ||
| Beq (amol/mm−2) | 9 (3 to 25) | 9 (4 to 23) | 28 (16 to 48)2-150 | 64 (46 to 90) | 50 (37 to 66) | 69 (49 to 97) | |
| Bmax(amol/mm−2) | NA | 118 (61 to 229) | 259 (154 to 435)† | NA | 380 (188 to 769)‡ | 360 (144 to 902) | |
| Kd (nM) | NA | 0.2 (0.1 to 0.3) | 0.3 (0.2 to 0.4) | NA | 0.1 (0.1 to 0.2) | 0.3 (0.1 to 0.5) | |
↵2-150 Significant heterogeneity between Beq values in stroma from patients with CMP, OA and RA (F=3.71, p=0.04). RA > OA and RA > CMP (p<0.05). †Bmax values for binding to stroma greater in RA than in OA (t=2.3, p=0.04).‡Bmax values greater for binding to blood vessels than to stroma in OA (t=6.1, p<0.001), but not in RA. No significant differences in Kd values were found between disease groups. Binding to blood vessels did not differ significantly between disease groups. Values are means (95% CI). Abbreviations: Beq ; equilibrium binding density, Bmax ; maximal binding capacity, Kd ; equilibrium dissociation constant, NA ; not assessed, CMP ; chondromalacia patellae, OA ; osteoarthritis, RA ; rheumatoid arthritis.